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in the hole

Meaning: Having lost money. Or in solitary confinement in prison. For example, "After playing roulette and losing I'm in the hole". Or, "He disobeyed the rules, throw him in the hole".

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in the gutter

Meaning: Having dirty thoughts. For example, "I want to talk about life but his mind is always in the gutter".

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in the flesh

Meaning: In person. For example, "Here I am, in the flesh".